Patients with the somatic rs121434569 TT genotype, (i.e. carrying two copies of the somatic T790M mutation) in combination with an activating EGFR mutation (e.g. L858R or exon 19 deletion) may have increased likelihood of acquired resistance to erlotinib as compared to patients with the CC genotype. Other genetic and clinical factors may also affect response to erlotinib.,临床等位基因

Patients with the somatic rs121434569 TT genotype, (i.e. carrying two copies of the somatic T790M mutation) in combination with an activating EGFR mutation (e.g. L858R or exon 19 deletion) may have increased likelihood of acquired resistance to erlotinib as compared to patients with the CC genotype. Other genetic and clinical factors may also affect response to erlotinib.

临床注释ID

981475450

基因型等位基因

TT

等位基因的功能