Patients with two copies of the CYP2A6*12 allele or one copy of the *12 allele in combination with one copy of the *1A or *9A alleles may have decreased metabolism of nicotine as compared to patients with two copies of the *1A allele. This annotation only covers the pharmacokinetic relationship between CYP2A6 and nicotine and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect nicotine metabolism.