The CYP2C9*29 allele has been assigned as a decreased function allele by CPIC. Patients carrying the CYP2C9*29 allele in combination with a normal function allele may have decreased metabolism of flurbiprofen as compared to patients carrying two normal function alleles. Other genetic and clinical factors may also influence flurbiprofen metabolism. This annotation only covers the pharmacokinetic relationship between CYP2C9 and flurbiprofen and does not include evidence about clinical outcomes.