化学ID

PA449053

化学名称(英)

clopidogrel

书本上化学名称

氯吡格雷

书本上化学名称(英)

clopidogrel

变体ID

PA165980635

变体名称

CYP2C19*2

变体类型

单倍型

变体类型(英)

Haplotype

变体名称文本

*2

基因身份证

PA124

基因符号

CYP2C19

基因文本

文学ID

PMID

32158254

文献标题

CYP2C19*17 May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban

出版年

2020

杂志

Pharmacogenomics and Personalized Medicine

句子

In some trials the variability in response to clopidogrel was observed, which is connected with numerous factors, CYP2C19-dependent active metabolite production among them. , Though the presence of low function alleles CYP2C19*2 ( rs4244285, c.681G>A ) and CYP2C19*3 ( rs4986893, c.636G>A ) leads to an insufficient platelet activity inhibition and significantly increases the risk of thrombotic complications compared to non-carriers. , CYP2C19*17 carriership is connected to an increased risk of bleeding complications on clopidogrel.

源

PGxMine