化学ID

PA451257

化学名称(英)

risperidone

书本上化学名称

利培酮

书本上化学名称(英)

risperidone

变体ID

PA166156025

变体名称

rs4818

变体类型

变体

变体类型(英)

Variant

变体名称文本

rs4818

基因身份证

PA117

基因符号

COMT

基因文本

文学ID

15103482

PMID

28696411

文献标题

Combined study of genetic and epigenetic biomarker risperidone treatment efficacy in Chinese Han schizophrenia patients.

出版年

2017

杂志

Translational psychiatry

句子

COMT , first discovered in 1957, has always been regarded as susceptibility gene in schizophrenia for its function of degrading catecholamine such as dopamine, epinephrine and norepinephrine. , Polymorphisms in COMT affected enzyme activity, for example, well-studied variant rs4680 G>A (substitution of valine to methionine at codon 158) resulted in decreased enzyme activity, which contributed to inefficient catalyzation and accumulation of dopamine, thus inducing positive symptoms in schizophrenia or even drug treatment failure. , Gupta et al. found that haplotype rs4818 and rs4680 in exon 4 was related with risperidone treatment response ( P =0.028) in 398 schizophrenia patients and 241 healthy individuals from a homogeneous South Indian population.

源

PGxMine