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呋塞米
文献标题
A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials.
杂志
The pharmacogenomics journal
句子
The primary objective of this pharmacogenetic meta-analysis was to test whether genetic variants previously shown to modulate the diuretic effects of loop diuretics ( SLC12A3 rs1529927, the SCNN1B2 haplotype [rs152728, rs152745, rs238547] and SCNN1G rs5723 and rs5729) are associated with net fluid loss (the total fluid output over 72 hours minus the total fluid input over 72 hours in mL) of a diuretic strategy based on intravenous furosemide at 72 hours after randomization in patients with decompensated HF.