化学ID

PA450704

化学名称(英)

omeprazole

书本上化学名称

奥美拉唑

书本上化学名称(英)

omeprazole

变体ID

PA165980635

变体名称

CYP2C19*2

变体类型

单倍型

变体类型(英)

Haplotype

变体名称文本

*2

基因身份证

PA124

基因符号

CYP2C19

基因文本

文学ID

15056836

PMID

23629159

文献标题

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent.

出版年

2014

杂志

The pharmacogenomics journal

句子

Third, reduction in AUC 0-鈭?of omeprazole and increase in metabolic ratio of 5-hydroxylation (changed from 0.04 to 0.08) observed in one PM subject (current study) are consistent with previous studies showing an increased omeprazole clearance in CYP2C19 PM after treatment with St-John's Wort or artemisinin. , Considering that CYP2C19*2*2 is associated with a complete absence of CYP2C19 activity, the induction observed in our PM subject and the magnitude thereof may be explained by induction of other non-CYP2C19-mediated metabolic pathways of omeprazole (e.g., CYP3A-mediated sulfoxidation).

源

PGxMine