奥美拉唑,PubMed 中的摘要说明，变体和药物之间的可能关系

奥美拉唑

化学ID

PA450704

化学名称(英)

omeprazole

书本上化学名称

奥美拉唑

书本上化学名称(英)

omeprazole

变体ID

PA165816533

变体名称

CYP2C19*17

变体类型

单倍型

变体类型(英)

Haplotype

变体名称文本

*17

基因身份证

PA124

基因符号

CYP2C19

基因文本

文学ID

15092369

PMID

26323597

文献标题

Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.

出版年

2016

杂志

The pharmacogenomics journal

句子

Individuals with the CYP2C19*17 variant are also reported to exhibit enhanced metabolic clearance of several other drugs, including omeprazole, amitriptyline, voriconazole and escitalopam. , Of the diplotypes that were observed in our study, the mean activity was greatly decreased in HLMs with the CYP2C19*2A/*2A diplotype compared with HLMs with a CYP2C19*1B/*1B diplotype.

源

PGxMine