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阿米替林
文献标题
Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.
杂志
The pharmacogenomics journal
句子
In contrast, the CYP2C19*17 allele has been associated with an enhanced efficacy of clopidogrel in reducing reoccurring cardiovascular events, risk of stent thrombosis and residual platelet aggregation, while increasing the risk of bleeding events. , Although not all clopidogrel study results are in agreement, the CYP2C19*17 allele has also been associated with enhanced metabolism of several other drugs, including omeprazole, amitriptyline, voriconazole, mephenytoin, pantoprazole and escitalopam.,