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 药物剂型-胶囊 409条(本栏目收费,不能显示细节,电话15274084725)
Preface Editors Contributors ...0 0
Chapter 1 Advances in Capsule Formulation Development and Technology.....1 Larry L. Augsburger and Stephen W. Hoag 1
Chapter 2 An Introduction to Two-Piece Hard Capsules and Their Marketing Benefits... 15 Dennis Murachanian 15
Chapter 3 Hard Shell Capsules in Clinical Trials... 31 Moji Christianah Adeyeye and Amusa Adebayo 31
Chapter 4 Capsule Shell Manufacture..... 75 Brian E. Jones, Fridrun Podczeck, and Paul Lukas 75
Chapter 5 Non-Gelatin-Based Capsules... 111 Sven Stegemann 111
Chapter 6 Hard Shell Capsule Filling Machines..... 131 Donald K. Lightfoot 131
Chapter 7 Instrumented Automatic Capsule Filling Machines and Filling Machine Simulation.... 191 Larry L. Augsburger and Vikas Moolchandani 191
Chapter 8 Dry-Fill Formulation and Filling Technology.... 211 Pavan Heda, Vikas Agarwal, and Shailesh K. Singh 211
Chapter 9 Plug Formation.... 237 Fridrun Podczeck 237
Chapter 10 Modeling Powder Filling during Encapsulation....283 Ammar Khawam 283
Chapter 11 Scale-Up and Transfer of Hard Shell Formulations across Machine Types....307 Larry L. Augsburger and Michael Levin viii Contents 307
Chapter 12 Modified-Release Delivery Systems: Extended-Release Capsule Platform.... 317 Reza Fassihi 317
Chapter 13 Analytical Testing and Evaluation of Capsules... 345 Stuart L. Cantor and Asish K. Dutta 345
Chapter 14 Rheological Aspects of Capsule Shell Excipients and the Manufacture of Encapsulated Formulations.... 373 Lawrence H. Block 373
Chapter 15 Quality-by-Design (QbD) for Capsule Formulation and Process Development:Regulatory Science Relevance, Scientific Case Studies, and Future Challenges.... 393 Huiquan Wu, Lin Xie, Stephen W. Hoag, Larry L. Augsburger,and Mansoor Khan 393
Alternative Shell Compositions....1 1
Unique Drug Delivery Systems....2 2
Liquid and Semisolid Capsule Filling...2 2
Using Capsules to Manage Poorly Soluble Drugs...3 3
Systematic Approaches for Understanding Hard Shell Capsule Formulation and Filling...5 5
Modeling of Plug Formation....5 5
Modeling in Support of Formulation Development.....5 5
Multivariate Analysis and Response Surface Methodology...6 6
Expert Systems.....9 9
Neuro-Nets (NNs).... 10 10
References..... 11 11
Introduction... 15 15
Market Growth of Two-Piece Hard Capsules... 16 16
Historical Development of the Capsule Dosage Form..... 17 17
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