药物剂型科学与技术 307条(本栏目收费,不能显示细节,电话15274084725)
Chapter 2 Hard Capsules in Modern Drug Delivery 21 S. Stegemann, W. Tian, M. Morgen and S. Brown 21
2.2 Hard Capsules—Types, Characteristics and Applications 22 22
2.2.1 Hard Capsules as a Pharmaceutical Excipient 22 22
2.2.2 Hard Capsules for Special Applications 25 25
2.3 Selection of Capsules in Formulation Development 29 29
2.4 Hard Capsule Drug Delivery Addressing Pharmaceutical Needs 29 29
2.4.1 Hard Capsule Powder Blend Formulation and Processing 29 29
2.4.2 Highly Potent and Low-dose Drug Formulations 32 32
2.4.3 Enhancing Bioavailability of Poorly Aqueous Soluble Drugs 33 33
2.4.4 Physical Modification of the Drug Substance 34 34
2.5 Targeted Drug Delivery 39 39
2.5.1 Capsules with Solid Formulation 39 39
2.5.2 Abuse Deterrent 42 42
2.6 Manufacture of Commercial Hard Capsules Products 43 43
2.6.1 Powder and Granule Blends 43 43
2.6.2 Multiparticulates and Mini-tablets 45 45
2.6.3 Tablet Filling 47 47
2.6.4 Liquid and Semi-solid Formulation 47 47
2.6.5 Powder Micro-dosing 48 48
Chapter 3 Soft Capsules 52 Stephen Tindal 52
3.3 Technology Strengths/Limitations 54 54
3.5 Equipment and Facilities 57 57
3.6 Shell Components 58 58