靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T99912

FORMERID

TTDR00950

UNIPROID

KYNU_HUMAN

TARGNAME

Kynureninase (KYNU)

GENENAME

KYNU

TARGTYPE

Preclinical target

SYNONYMS

L-kynurenine hydrolase; KYNU

FUNCTION

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

PDBSTRUC

3E9K; 2HZP

BIOCLASS

Carbon-carbon bonds hydrolase

ECNUMBER

EC 3.7.1.3

SEQUENCE

MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN

DRUGINFO

D17TRG

2-Amino-4-[3-hydroxyphenyl]-4-hydroxybutanoic acid

Preclinical

DRUGINFO

D6QA4N

S-(2-Aminophenyl)-L-cysteine S,S-dioxide

Preclinical

DRUGINFO

D02DWE

3,6,9,12,15-Pentaoxaheptadecane

Investigative

DRUGINFO

D0V4AX

3-hydroxydesaminokynurenine

Investigative

DRUGINFO

D05JZS

3-Hydroxyhippuric acid

Investigative

DRUGINFO

D00ASH

3-methoxydesaminokynurenine

Investigative

KEGGPATH

hsa00380:Tryptophan metabolism

KEGGPATH

hsa01100:Metabolic pathways

目标的 KEGG 通路数据

标题	内容
hsa00380	Tryptophan metabolism
hsa01100	Metabolic pathways

目标的 Wiki 路径数据

标题	内容
WP465	Tryptophan metabolism
WP2693	Metabolism of amino acids and derivatives
WP2485	NAD Biosynthesis II (from tryptophan)
WP15	Selenium Micronutrient Network

目标的蛋白质ID

标题	内容
TARGETID	T99912
UNIPROID	KYNU_HUMAN
TARGNAME	Kynureninase (KYNU)
TARGTYPE	Preclinical target

目标的序列数据

标题	内容
Kynureninase (KYNU)	MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN

标题

内容

Kynureninase (KYNU)

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