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靶点信息25(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Trace amine-associated receptor-1 (TAAR1)
TARGTYPE
Successful target
SYNONYMS
Trace amine receptor 1; TaR-1; TAAR1
FUNCTION
Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines,such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amineshave clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
SEQUENCE
MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
DRUGINFO
Dextroamphetamine
DRUGINFO
Hydroxyamphetamine Hydrobromide
DRUGINFO
Lisdexamfetamine
DRUGINFO
3-iodothyronamine
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Trace amine-associated receptor-1 (TAAR1) |
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