TARGETID

T99397

UNIPROID

VDAC1_HUMAN

TARGNAME

Voltage-dependent anion-selective channel 1 (VDAC1)

GENENAME

VDAC1

TARGTYPE

Clinical trial target

SYNONYMS

Porin 31HM; Porin 31HL; Plasmalemmal porin; Outer mitochondrial membrane protein porin 1

FUNCTION

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).

PDBSTRUC

6G73; 6G6U; 5XDO; 5XDN; 5JDP

BIOCLASS

Eukaryotic mitochondrial porin

SEQUENCE

MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA

DRUGINFO

VDA-1102

KEGGPATH

hsa04020:Calcium signaling pathway

KEGGPATH

hsa04022:cGMP-PKG signaling pathway

KEGGPATH

hsa04217:Necroptosis

KEGGPATH

hsa04218:Cellular senescence

KEGGPATH

hsa04621:NOD-like receptor signaling pathway

KEGGPATH

hsa04979:Cholesterol metabolism

KEGGPATH

hsa05012:Parkinson disease

KEGGPATH

hsa05016:Huntington disease

KEGGPATH

hsa05164:Influenza A