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靶点信息11(本栏目收费,不能显示细节,电话13136136841)

靶点信息

标题

内容

相关药物

状态

TARGETID

T99394

FORMERID

TTDR00935

UNIPROID

TR13B_HUMAN

TARGNAME

Transmembrane activator and CAML interactor (TNFRSF13B)

GENENAME

TNFRSF13B

TARGTYPE

Clinical trial target

SYNONYMS

Tumor necrosis factor receptor superfamily member 13B; TACI; CD267

FUNCTION

Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity.

PDBSTRUC

1XUT; 1XU1

SEQUENCE

MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGSPVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPDSGLGIVCVPAQEGGPGA

DRUGINFO

D0B8UW

AUTO2

Phase 1/2

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T99394
UNIPROID	TR13B_HUMAN
TARGNAME	Transmembrane activator and CAML interactor (TNFRSF13B)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Transmembrane activator and CAML interactor (TNFRSF13B)	MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGSPVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPDSGLGIVCVPAQEGGPGA

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