靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T97257

FORMERID

TTDR00511

UNIPROID

TGFB1_HUMAN

TARGNAME

Transforming growth factor beta 1 (TGFB1)

GENENAME

TGFB1

TARGTYPE

Successful target

SYNONYMS

Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1; TGFB; TGF-beta1; TGF-beta 1

FUNCTION

Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.

PDBSTRUC

5VQP; 5FFO; 4KV5; 3KFD; 1KLD

BIOCLASS

Growth factor

SEQUENCE

MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

DRUGINFO

Pirfenidone

DRUGINFO

TG-C

DRUGINFO

LY2157299

DRUGINFO

Disitertide

DRUGINFO

ABBV-151

DRUGINFO

SRK-181

DRUGINFO

Mannose phosphate

Discontinued in Phase 2

DRUGINFO

D08OLR

ART-144

Investigative

KEGGPATH

hsa04010:MAPK signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05152	Tuberculosis
hsa05161	Hepatitis B
hsa05166	HTLV-I infection
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05220	Chronic myeloid leukemia
hsa05321	Inflammatory bowel disease (IBD)
hsa05323	Rheumatoid arthritis
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05414	Dilated cardiomyopathy
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04068	FoxO signaling pathway
hsa04110	Cell cycle
hsa04144	Endocytosis
hsa04350	TGF-beta signaling pathway
hsa04380	Osteoclast differentiation
hsa04390	Hippo signaling pathway
hsa04672	Intestinal immune network for IgA production

目标的 Wiki 路径数据

标题	内容
WP710	DNA Damage Response (only ATM dependent)
WP69	TCR Signaling Pathway
WP615	Senescence and Autophagy in Cancer
WP560	TGF Beta Signaling Pathway
WP554	ACE Inhibitor Pathway
WP530	Cytokines and Inflammatory Response
WP474	Endochondral Ossification
WP382	MAPK Signaling Pathway
WP366	TGF beta Signaling Pathway
WP2884	NRF2 pathway
WP2882	Nuclear Receptors Meta-Pathway
WP2877	Vitamin D Receptor Pathway
WP2873	Aryl Hydrocarbon Receptor Pathway
WP2870	Extracellular vesicle-mediated signaling in recipient cells
WP286	IL-3 Signaling Pathway
WP2855	Dopaminergic Neurogenesis
WP2853	Endoderm Differentiation
WP2849	Hematopoietic Stem Cell Differentiation
WP2848	Differentiation Pathway
WP2840	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WP2795	Cardiac Hypertrophic Response
WP2787	Syndecan interactions
WP2771	Host Interactions with Influenza Factors
WP2751	Transcriptional Regulation of White Adipocyte Differentiation
WP2742	Signaling by TGF-beta Receptor Complex
WP2703	Extracellular matrix organization
WP2666	Elastic fibre formation
WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
WP2431	Spinal Cord Injury
WP2406	Cardiac Progenitor Differentiation
WP2377	Integrated Pancreatic Cancer Pathway
WP236	Adipogenesis
WP2355	Corticotropin-releasing hormone
WP2332	Interleukin-11 Signaling Pathway
WP2328	Allograft Rejection
WP179	Cell Cycle
WP1559	TFs Regulate miRNAs related to cardiac hypertrophy
WP1544	MicroRNAs in cardiomyocyte hypertrophy

目标的蛋白质ID

标题	内容
TARGETID	T97257
UNIPROID	TGFB1_HUMAN
TARGNAME	Transforming growth factor beta 1 (TGFB1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Transforming growth factor beta 1 (TGFB1)	MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

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