TARGETID

T95678

FORMERID

TTDS00175

UNIPROID

M2_I34A1

TARGNAME

Influenza M2 protein (Influ M)

GENENAME

Influ M

TARGTYPE

Successful target

SYNONYMS

Matrix protein M2; M2 proton channel; M

FUNCTION

Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.

PDBSTRUC

5DLM

BIOCLASS

Influenza viruses matrix protein

SEQUENCE

MSLLTEVETPIRNEWGCRCNGSSDPLAIAANIIGILHLILWILDRLFFKCIYRRFKYGLKGGPSTEGVPKSMREEYRKEQQSAVDADDGHFVSIELE

DRUGINFO

Amantadine

DRUGINFO

Rimantadine

DRUGINFO

TCN-032

DRUGINFO

2-(1-adamantyl) piperidine

DRUGINFO

2-(1-adamantyl) pyrrolidine

DRUGINFO

2-(1-adamantyl)-2-methyl-pyrrolidine

DRUGINFO

2-(2-adamantyl) piperidine

DRUGINFO

3-(2-adamantyl) pyrrolidine

DRUGINFO

B-Octylglucoside