TARGETID

T94692

FORMERID

TTDR00225

UNIPROID

LDLR_HUMAN

TARGNAME

Low-density lipoprotein receptor (LDL-R)

GENENAME

LDLR

TARGTYPE

Successful target

SYNONYMS

LDL receptor

FUNCTION

In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.

PDBSTRUC

5OYL; 5OY9; 4NE9; 3SO6; 3P5C

BIOCLASS

Low density lipoprotein receptor

SEQUENCE

MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA

DRUGINFO

Porfimer Sodium

DRUGINFO

Alpha-D-Mannose

KEGGPATH

hsa04144:Endocytosis

KEGGPATH

hsa04913:Ovarian steroidogenesis

KEGGPATH

hsa04976:Bile secretion

KEGGPATH

hsa05145:Toxoplasmosis

KEGGPATH

hsa05160:Hepatitis C

WIKIPATH

WP15:Selenium Micronutrient Network

WIKIPATH

WP1533:Vitamin B12 Metabolism