TARGETID

T94324

FORMERID

TTDR01338

UNIPROID

HDA10_HUMAN

TARGNAME

Histone deacetylase 10 (HDAC10)

GENENAME

HDAC10

TARGTYPE

Patented-recorded target

SYNONYMS

Polyamine deacetylase HDAC10; HD10

FUNCTION

Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair. Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine.

BIOCLASS

Carbon-nitrogen hydrolase

ECNUMBER

EC 3.5.1.48

SEQUENCE

MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA

DRUGINFO

PMID29671355-Compound-21

DRUGINFO

PMID29671355-Compound-25

DRUGINFO

PMID29671355-Compound-43

DRUGINFO

PMID29671355-Compound-44

DRUGINFO

PMID29671355-Compound-56

DRUGINFO

PMID29671355-Compound-62

DRUGINFO

PMID29671355-Compound-8

DRUGINFO

(E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one

DRUGINFO

2-(methylsulfonylthio)ethyl 2-propylpentanoate