TARGETID

T94085

FORMERID

TTDS00073

UNIPROID

RARA_HUMAN

TARGNAME

Retinoic acid receptor alpha (RARA)

GENENAME

RARA

TARGTYPE

Clinical trial target

SYNONYMS

RAR-alpha; RAR alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1

FUNCTION

Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Receptor for retinoic acid.

PDBSTRUC

5K13; 4DQM; 3KMZ; 3KMR; 3A9E

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP

DRUGINFO

Tamibarotene

DRUGINFO

IRX-5183

DRUGINFO

SY-1425

DRUGINFO

PMID27336223-Compound-4

DRUGINFO

PMID27336223-Compound-5

DRUGINFO

LG100268

DRUGINFO

AGN193109

DRUGINFO

AGN193836

DRUGINFO

BMS614