靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T94033

FORMERID

TTDS00202

UNIPROID

THRB_HUMAN

TARGNAME

Coagulation factor IIa (F2)

GENENAME

F2

TARGTYPE

Successful target

SYNONYMS

Prothrombin; Coagulation factor II

FUNCTION

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

PDBSTRUC

8KME; 7KME; 6EO9; 6EO8; 6EO7

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.21.5

SEQUENCE

MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE

DRUGINFO

Anisindione

DRUGINFO

Argatroban

DRUGINFO

ATryn antithrombin

DRUGINFO

Bivalirudin

DRUGINFO

Dabigatran

DRUGINFO

Desirudin Recombinant

Approved

DRUGINFO

D07KFG

Human prothrombin complex concentrate

Approved

DRUGINFO

D09LPN

Lepirudin

Approved

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction
hsa04610	Complement and coagulation cascades
hsa04810	Regulation of actin cytoskeleton

目标的 Wiki 路径数据

标题	内容
WP558	Complement and Coagulation Cascades
WP51	Regulation of Actin Cytoskeleton
WP2865	IL1 and megakaryotyces in obesity
WP2799	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP2762	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
WP272	Blood Clotting Cascade
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP1929	Thrombin signalling through proteinase activated receptors (PARs)
WP1884	Platelet Aggregation (Plug Formation)
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP1818	Formation of Fibrin Clot (Clotting Cascade)
WP1794	Cell surface interactions at the vascular wall
WP176	Folate Metabolism
WP1533	Vitamin B12 Metabolism
WP15	Selenium Micronutrient Network

目标的蛋白质ID

标题	内容
TARGETID	T94033
UNIPROID	THRB_HUMAN
TARGNAME	Coagulation factor IIa (F2)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Coagulation factor IIa (F2)	MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE

标题

内容

Coagulation factor IIa (F2)

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