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靶点信息11(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Ubiquitin-like protein Nedd8 (NEDD8)
TARGTYPE
Clinical trial target
SYNONYMS
Neural precursor cell expressed developmentally down-regulated protein 8; Neddylin; NEDD-8
FUNCTION
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
PDBSTRUC
4P5O; 4HCP; 4FBJ; 4F8C; 3GZN
BIOCLASS
Ubiquitin family
SEQUENCE
MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLRQ
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Ubiquitin-like protein Nedd8 (NEDD8) |
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