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靶点信息

标题

内容

相关药物

状态

TARGETID

T93923

FORMERID

TTDNC00406

UNIPROID

TNR9_HUMAN

TARGNAME

Co-stimulatory molecule 4-1BB (CD137)

GENENAME

TNFRSF9

TARGTYPE

Clinical trial target

SYNONYMS

Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA; T-cell antigen 4-1BB homolog; ILA; CDw137; 4-1BB ligand receptor

FUNCTION

Possibly active during T cell activation. Receptor for TNFSF9/4-1BBL.

PDBSTRUC

6MI2; 6MHR; 6MGP; 6CU0; 6CPR

BIOCLASS

Cytokine receptor

SEQUENCE

MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL

DRUGINFO

Anti-CD137

DRUGINFO

Urelumab

DRUGINFO

ADG106

DRUGINFO

CD137 CAR-T Cell

DRUGINFO

MG7-CART

DRUGINFO

NM21-1480

DRUGINFO

AGEN2373

DRUGINFO

AMG 506

DRUGINFO

CD28 and CD137 CAR-T Cells

Phase 1

目标的 KEGG 通路数据

标题	内容
hsa04060	Cytokine-cytokine receptor interaction

目标的 Wiki 路径数据

标题	内容
WP69	TCR Signaling Pathway

目标的蛋白质ID

标题	内容
TARGETID	T93923
UNIPROID	TNR9_HUMAN
TARGNAME	Co-stimulatory molecule 4-1BB (CD137)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Co-stimulatory molecule 4-1BB (CD137)	MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL

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