靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T93788

FORMERID

TTDC00050

UNIPROID

GP119_HUMAN

TARGNAME

Glucose-dependent insulinotropic receptor (GPR119)

GENENAME

GPR119

TARGTYPE

Successful target

SYNONYMS

GPR119; G-protein coupled receptor 119

FUNCTION

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG

DRUGINFO

D07ILQ

Guanfacine extended release

DRUGINFO

DS-8500

DRUGINFO

GSK1292263

DRUGINFO

SAR-260093

DRUGINFO

APD-597

DRUGINFO

BMS-903452

DRUGINFO

DA-1241

DRUGINFO

APD668

Discontinued in Phase 1

DRUGINFO

D0F1KP

PSN821

Terminated

DRUGINFO

D0S4FV

(R)-N-oleoyltyrosinol

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04024	cAMP signaling pathway
hsa04911	Insulin secretion

目标的 Wiki 路径数据

标题	内容
WP2728	Incretin Synthesis, Secretion, and Inactivation

目标的蛋白质ID

标题	内容
TARGETID	T93788
UNIPROID	GP119_HUMAN
TARGNAME	Glucose-dependent insulinotropic receptor (GPR119)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Glucose-dependent insulinotropic receptor (GPR119)	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG

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