TARGETID

T93661

FORMERID

TTDR01343

UNIPROID

SMAD7_HUMAN

TARGNAME

Smad7 messenger RNA (Smad7 mRNA)

GENENAME

SMAD7

TARGTYPE

Clinical trial target

SYNONYMS

hSMAD7 (mRNA); Smad7 (mRNA); SMAD family member 7 (mRNA); SMAD 7 (mRNA); Mothers against decapentaplegic homolog 8 (mRNA); Mothers against decapentaplegic homolog 7 (mRNA); Mothers against DPP homolog 8 (mRNA); Mothers against DPP homolog 7 (mRNA); MADH8 (mRNA); MADH7 (mRNA); MAD homolog 8 (mRNA); MAD homolog 7 (mRNA)

FUNCTION

Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access.

PDBSTRUC

2LTZ; 2LTY; 2LTX; 2LTW; 2LTV

BIOCLASS

mRNA target

SEQUENCE

MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR

DRUGINFO

GED-0301

DRUGINFO

ISIS 28465

DRUGINFO

ISIS 28466

DRUGINFO

ISIS 28472

DRUGINFO

ISIS 28477

KEGGPATH

hsa04144:Endocytosis

KEGGPATH

hsa04350:TGF-beta signaling pathway

KEGGPATH

hsa04390:Hippo signaling pathway

WIKIPATH

WP1984:Integrated Breast Cancer Pathway