靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T93566

FORMERID

TTDR01369

UNIPROID

LOX5_HUMAN

TARGNAME

LOX-5 messenger RNA (ALOX5 mRNA)

GENENAME

ALOX5

TARGTYPE

Discontinued target

SYNONYMS

LOG5 (mRNA); 5-lipoxygenase (mRNA); 5-LO (mRNA)

FUNCTION

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

PDBSTRUC

3V99; 3V98; 3V92; 3O8Y; 2ABV

BIOCLASS

mRNA target

ECNUMBER

EC 1.13.11.34

SEQUENCE

MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI

DRUGINFO

D0P3KA

TEBUFELONE

Discontinued in Phase 2

DRUGINFO

D07HBI

ZD-2138

Discontinued in Phase 2

DRUGINFO

D05WPQ

BW A4C

Terminated

DRUGINFO

D0N7XM

(-)-3,3'-bisdemethylpinoresinol

DRUGINFO

(-)-pinoresinol

DRUGINFO

(+)-3,3'-bisdemethyltanegool

Investigative

DRUGINFO

D0UH6R

(N-(3-phenoxycinnamyl)-acetohydroxamic acid

Investigative

DRUGINFO

D09XWS

1-(4-methoxyphenyl)-3-(1,3,4-thiadiazol-2-yl)urea

Investigative

目标的 KEGG 通路数据

标题	内容
hsa00590	Arachidonic acid metabolism
hsa01100	Metabolic pathways
hsa04726	Serotonergic synapse
hsa04913	Ovarian steroidogenesis
hsa05145	Toxoplasmosis

目标的 Wiki 路径数据

标题	内容
WP2650	Arachidonic acid metabolism
WP167	Eicosanoid Synthesis
WP15	Selenium Micronutrient Network

目标的蛋白质ID

标题	内容
TARGETID	T93566
UNIPROID	LOX5_HUMAN
TARGNAME	LOX-5 messenger RNA (ALOX5 mRNA)
TARGTYPE	Discontinued target

目标的序列数据

标题	内容
LOX-5 messenger RNA (ALOX5 mRNA)	MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI

标题

内容

LOX-5 messenger RNA (ALOX5 mRNA)

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