靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T93515

FORMERID

TTDC00179

UNIPROID

P2RY2_HUMAN

TARGNAME

P2Y purinoceptor 2 (P2RY2)

GENENAME

P2RY2

TARGTYPE

Clinical trial target

SYNONYMS

P2Y2; P2U1; P2U receptor; P2U purinoceptor 1; P2U nucleotide receptor; P2RY2; Adenosine P2Y2 receptor

FUNCTION

Receptor for ATP and UTP coupled to G-proteins thatactivate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

PDBSTRUC

1Z8E

BIOCLASS

GPCR rhodopsin

SEQUENCE

MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL

DRUGINFO

Diquafosol

DRUGINFO

INS-37217

DRUGINFO

INS 316

Discontinued in Phase 3

DRUGINFO

2-thioUTP

DRUGINFO

4-thio-UTP

DRUGINFO

5BrUTP

DRUGINFO

Acid blue 25

DRUGINFO

AR-C118925XX

DRUGINFO

AR-C126313

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction
hsa04750	Inflammatory mediator regulation of TRP channels

目标的 Wiki 路径数据

标题	内容
WP80	Nucleotide GPCRs
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T93515
UNIPROID	P2RY2_HUMAN
TARGNAME	P2Y purinoceptor 2 (P2RY2)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
P2Y purinoceptor 2 (P2RY2)	MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL

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