TARGETID

T93122

FORMERID

TTDNC00645

UNIPROID

BDNF_HUMAN

TARGNAME

Brain-derived neurotrophic factor (BDNF)

GENENAME

BDNF

TARGTYPE

Clinical trial target

SYNONYMS

Brainderived neurotrophic factor; Abrineurin

FUNCTION

Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems.

PDBSTRUC

1BND; 1B8M

BIOCLASS

Growth factor

SEQUENCE

MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR

DRUGINFO

PYM-50028

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04024:cAMP signaling pathway

KEGGPATH

hsa04722:Neurotrophin signaling pathway

KEGGPATH

hsa05016:Huntington's disease

KEGGPATH

hsa05030:Cocaine addiction

KEGGPATH

hsa05034:Alcoholism

WIKIPATH

WP2004:miR-targeted genes in lymphocytes - TarBase

WIKIPATH

WP2035:FSH signaling pathway