靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T92828

FORMERID

TTDS00199

UNIPROID

EDNRB_HUMAN

TARGNAME

Endothelin B receptor (EDNRB)

GENENAME

EDNRB

TARGTYPE

Successful target

SYNONYMS

Endothelin receptor type B; Endothelin receptor Non-selective type; Endothelin receptor B; ETRB; ET-BR; ET-B

FUNCTION

Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Non-specific receptor for endothelin 1, 2, and 3.

PDBSTRUC

6IGL; 6IGK; 5XPR; 5X93; 5GLI

BIOCLASS

GPCR rhodopsin

SEQUENCE

MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS

DRUGINFO

Bosentan

DRUGINFO

Macitentan

DRUGINFO

BQ788

DRUGINFO

PD-145065

DRUGINFO

SPI-1620

DRUGINFO

ENRASENTAN

Discontinued in Phase 2

DRUGINFO

D05VZJ

J-104132

Discontinued in Phase 2

DRUGINFO

D0W6XL

SB-209670

Discontinued in Phase 2

DRUGINFO

D05OEO

ET-1

Phase 0

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04916	Melanogenesis
hsa05200	Pathways in cancer

目标的 Wiki 路径数据

标题	内容
WP98	Prostaglandin Synthesis and Regulation
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP24	Peptide GPCRs
WP2197	Endothelin Pathways
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T92828
UNIPROID	EDNRB_HUMAN
TARGNAME	Endothelin B receptor (EDNRB)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Endothelin B receptor (EDNRB)	MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS

标题

内容

Endothelin B receptor (EDNRB)

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