靶点信息25(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Cytochrome P450 24 (CYP24A1)
TARGTYPE
Clinical trial target
SYNONYMS
Vitamin D(3) 24hydroxylase; Cytochrome P450CC24; CYP24A1; 24OHase; 1,25dihydroxyvitamin D(3) 24hydroxylase, mitochondrial
FUNCTION
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
BIOCLASS
Paired donor oxygen oxidoreductase
SEQUENCE
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
KEGGPATH
hsa00100:Steroid biosynthesis
KEGGPATH
hsa01100:Metabolic pathways
KEGGPATH
hsa05206:MicroRNAs in cancer
WIKIPATH
WP1531:Vitamin D Metabolism
WIKIPATH
WP1879:Phase 1 - Functionalization of compounds
WIKIPATH
WP2749:Metabolism of steroid hormones and vitamin D
WIKIPATH
WP2877:Vitamin D Receptor Pathway
WIKIPATH
WP299:Nuclear Receptors in Lipid Metabolism and Toxicity
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00100 |
|
| hsa01100 |
|
| hsa05206 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP702 |
|
| WP43 |
|
| WP299 |
|
| WP2877 |
|
| WP2749 |
|
| WP1879 |
|
| WP1531 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Cytochrome P450 24 (CYP24A1) |
|