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靶点信息19(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Proto-oncogene Mas (MAS)
TARGTYPE
Clinical trial target
SYNONYMS
MGRA; MAS1 proto-oncogene, G protein-coupled receptor
FUNCTION
Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Receptor for angiotensin 1-7.
SEQUENCE
MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV
DRUGINFO
Angiotensin-(1-7)
KEGGPATH
hsa04080:Neuroactive ligand-receptor interaction
KEGGPATH
hsa04614:Renin-angiotensin system
WIKIPATH
WP455:GPCRs, Class A Rhodopsin-like
WIKIPATH
WP554:ACE Inhibitor Pathway
目标的蛋白质ID
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目标的序列数据
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| Proto-oncogene Mas (MAS) |
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