TARGETID

T90572

FORMERID

TTDR00252

UNIPROID

IGF2_HUMAN

TARGNAME

Insulin-like growth factor-II (IGF2)

GENENAME

IGF2

TARGTYPE

Clinical trial target

SYNONYMS

T3M-11-derived growth factor; Somatomedin-A; Somatomedin A; PP1446; Insulin-like growth factor II; Insulin-like growth factor 2; IGF-II

FUNCTION

Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. The insulin-like growth factors possess growth-promoting activity.

PDBSTRUC

5L3N; 5L3M; 5L3L; 3KR3; 3E4Z

SEQUENCE

MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK

DRUGINFO

Dusigitumab

DRUGINFO

Xentuzumab