TARGETID

T89697

FORMERID

TTDS00476

UNIPROID

I23O1_HUMAN

TARGNAME

Indoleamine 2,3-dioxygenase 1 (IDO1)

GENENAME

IDO1

TARGTYPE

Successful target

SYNONYMS

Indoleamine-pyrrole 2,3-dioxygenase; INDO; IDO-1; IDO

FUNCTION

Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection. Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway.

PDBSTRUC

6MQ6; 6F0A; 6DPR; 6DPQ; 6CXV

BIOCLASS

Oxygenase

ECNUMBER

EC 1.13.11.52

SEQUENCE

MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG

DRUGINFO

L-Tryptophan

DRUGINFO

Avastin+/-Tarceva

DRUGINFO

BMS-986205

DRUGINFO

INCB24360

DRUGINFO

NLG8189

DRUGINFO

DN1406131

DRUGINFO

HTI-1090

DRUGINFO

KHK2455