TARGETID

T89360

FORMERID

TTDS00063

UNIPROID

IMDH2_HUMAN

TARGNAME

Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

GENENAME

IMPDH2

TARGTYPE

Successful target

SYNONYMS

IMPDH-II; IMPDH 2; IMPD2; IMPD 2; IMP dehydrogenase 2

FUNCTION

Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

PDBSTRUC

6I0O; 6I0M; 1NFB; 1NF7; 1B3O

BIOCLASS

CH-OH donor oxidoreductase

ECNUMBER

EC 1.1.1.205

SEQUENCE

MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF

DRUGINFO

Mycophenolate mofetil

DRUGINFO

Urea and carbamate bioisostere derivative 1

DRUGINFO

1-(3-cyano-1-methyl-1H-indol-6-yl)-3-phenylurea

DRUGINFO

1-methoxy-3-(3-(pyridin-4-yl)-1H-indol-6-yl)urea

DRUGINFO

1-methyl-1H-indole-3-carbaldehyde

DRUGINFO

1-methyl-1H-indole-3-carbonitrile

DRUGINFO

1-methyl-1H-indole-3-carboxamide

DRUGINFO

2-Benzyl-6-methoxy-5-oxazol-5-yl-1H-indole