TARGETID

T88505

FORMERID

TTDNR00714

UNIPROID

NF2L2_HUMAN

TARGNAME

Nuclear factor erythroid 2-related factor 2 (Nrf2)

GENENAME

NFE2L2

TARGTYPE

Clinical trial target

SYNONYMS

Nuclear factor, erythroid derived 2, like 2; NRF2; NFE2-related factor 2; NF-E2-related factor 2; HEBP1

FUNCTION

Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes.

PDBSTRUC

5WFV; 4IFL; 3ZGC; 2LZ1; 2FLU

BIOCLASS

Basic leucine zipper bZIP

SEQUENCE

MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN

DRUGINFO

ABT-RTA-408

DRUGINFO

CXA10

DRUGINFO

Omaveloxolone

DRUGINFO

OT551

DRUGINFO

OT-551

DRUGINFO

SFX-01

DRUGINFO

HPP971

DRUGINFO

1,2,3,4-tetrahydroisoquinoline derivative 1

DRUGINFO

1-phenyl-1,3,4-triazole derivative 1