靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T88430

FORMERID

TTDR01370

UNIPROID

ARAF_HUMAN

TARGNAME

A-Raf messenger RNA (ARAF mRNA)

GENENAME

ARAF

TARGTYPE

Clinical trial target

SYNONYMS

Serine/threonine-protein kinase A-Raf (mRNA); Proto-oncogene Pks (mRNA); Proto-oncogene A-Raf-1 (mRNA); Proto-oncogene A-Raf (mRNA); PKS2 (mRNA); PKS (mRNA); ARAF1 (mRNA)

FUNCTION

May also regulate the TOR signaling cascade. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.

PDBSTRUC

2MSE; 1WXM

BIOCLASS

mRNA target

ECNUMBER

EC 2.7.11.1

SEQUENCE

MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP

DRUGINFO

RG7304

DRUGINFO

ISIS 10228

DRUGINFO

ISIS 9060

DRUGINFO

ISIS 9061

DRUGINFO

ISIS 9062

DRUGINFO

ISIS 9063

DRUGINFO

ISIS 9064

DRUGINFO

ISIS 9065

目标的 KEGG 通路数据

标题	内容
hsa04012	ErbB signaling pathway
hsa04068	FoxO signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04650	Natural killer cell mediated cytotoxicity
hsa04720	Long-term potentiation
hsa04726	Serotonergic synapse
hsa04730	Long-term depression
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa05034	Alcoholism
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05223	Non-small cell lung cancer

目标的 Wiki 路径数据

标题	内容
WP673	ErbB Signaling Pathway
WP422	MAPK Cascade
WP2261	Signaling Pathways in Glioblastoma
WP1984	Integrated Breast Cancer Pathway
WP185	Integrin-mediated Cell Adhesion

目标的蛋白质ID

标题	内容
TARGETID	T88430
UNIPROID	ARAF_HUMAN
TARGNAME	A-Raf messenger RNA (ARAF mRNA)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
A-Raf messenger RNA (ARAF mRNA)	MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP

标题

内容

A-Raf messenger RNA (ARAF mRNA)

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