TARGETID

T87075

FORMERID

TTDS00473

UNIPROID

CD3E_HUMAN

TARGNAME

T-cell surface glycoprotein CD3 epsilon (CD3E)

GENENAME

CD3E

TARGTYPE

Successful target

SYNONYMS

T3E; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e

FUNCTION

When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.

PDBSTRUC

2ROL; 1XIW; 1SY6; 1A81

SEQUENCE

MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI

DRUGINFO

Muromonab

DRUGINFO

Ertumaxomab

DRUGINFO

Resimmune

DRUGINFO

Autologous T-cell therapy

DRUGINFO

MT-110

KEGGPATH

hsa04640:Hematopoietic cell lineage

KEGGPATH

hsa04660:T cell receptor signaling pathway

KEGGPATH

hsa05142:Chagas disease (American trypanosomiasis)

KEGGPATH

hsa05162:Measles

KEGGPATH

hsa05166:HTLV-I infection