TARGETID

T86552

FORMERID

TTDNC00502

UNIPROID

TNR1A_HUMAN

TARGNAME

Tumor necrosis factor receptor type I (TNF-R1)

GENENAME

TNFRSF1A

TARGTYPE

Clinical trial target

SYNONYMS

p60; p55; Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNFR1; TNFR-I; TNFAR; TNF-RI; TBPI; CD120a

FUNCTION

The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha.

PDBSTRUC

1TNR; 1NCF; 1ICH; 1FT4; 1EXT

BIOCLASS

Cytokine receptor

SEQUENCE

MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR

DRUGINFO

VB-111

DRUGINFO

Drug 2862277

DRUGINFO

AVX-470

DRUGINFO

GSK1995057

DRUGINFO

Anti-IFN gamma

DRUGINFO

ADS-0101

DRUGINFO

ALF-421

DRUGINFO

Anti-TNF human mabs

DRUGINFO

NM-2014