TARGETID

T85670

FORMERID

TTDI02219

UNIPROID

NGF_HUMAN

TARGNAME

Nerve growth factor (NGF)

GENENAME

NGF

TARGTYPE

Clinical trial target

SYNONYMS

NGFB; Beta-nerve growth factor; Beta-NGF

FUNCTION

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).

PDBSTRUC

5JZ7; 4ZBN; 4EDX; 4EDW; 2IFG

BIOCLASS

Growth factor

SEQUENCE

MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA

DRUGINFO

Fasinumab

DRUGINFO

Tanezumab

DRUGINFO

SAR164877

DRUGINFO

CERE-110

DRUGINFO

CXB-909

DRUGINFO

ABT-110

DRUGINFO

MEDI-578

DRUGINFO

NsG-0202

DRUGINFO

Nerve growth factor