靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T85651

FORMERID

TTDI02268

UNIPROID

MYC_HUMAN

TARGNAME

Myc messenger RNA (MYC mRNA)

GENENAME

MYC

TARGTYPE

Clinical trial target

SYNONYMS

bHLHe39 (mRNA); Transcription factor p64 (mRNA); Proto-oncogene c-Myc (mRNA); Myc proto-oncogene protein (mRNA); Class E basic helix-loop-helix protein 39 (mRNA); C-myc oncogene (mRNA); C-myc (mRNA)

FUNCTION

Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.

PDBSTRUC

6G6L; 6G6K; 6G6J; 6C4U; 5I50

BIOCLASS

mRNA target

SEQUENCE

MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA

DRUGINFO

AVI-5126

DRUGINFO

Resten-NG

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04012:ErbB signaling pathway

KEGGPATH

hsa04110:Cell cycle

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04310:Wnt signaling pathway

KEGGPATH

hsa04350:TGF-beta signaling pathway

KEGGPATH

hsa04390:Hippo signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04110	Cell cycle
hsa04151	PI3K-Akt signaling pathway
hsa04310	Wnt signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04390	Hippo signaling pathway
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04630	Jak-STAT signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa05161	Hepatitis B
hsa05166	HTLV-I infection
hsa05169	Epstein-Barr virus infection
hsa05200	Pathways in cancer
hsa05202	Transcriptional misregulation in cancer
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer
hsa05210	Colorectal cancer
hsa05213	Endometrial cancer
hsa05216	Thyroid cancer
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05222	Small cell lung cancer
hsa05230	Central carbon metabolism in cancer

目标的 Wiki 路径数据

标题	内容
WP710	DNA Damage Response (only ATM dependent)
WP707	DNA Damage Response
WP673	ErbB Signaling Pathway
WP61	Notch Signaling Pathway
WP49	IL-2 Signaling Pathway
WP45	G1 to S cell cycle control
WP428	Wnt Signaling Pathway
WP400	p38 MAPK Signaling Pathway
WP399	Wnt Signaling Pathway and Pluripotency
WP382	MAPK Signaling Pathway
WP366	TGF beta Signaling Pathway
WP363	Wnt Signaling Pathway Netpath
WP2878	PPAR Alpha Pathway
WP2858	Ectoderm Differentiation
WP2839	Hair Follicle Development: Organogenesis (Part 2 of 3)
WP2828	Bladder Cancer
WP2815	Mammary gland development pathway - Involution (Stage 4 of 4)
WP2804	Hair Follicle Development: Induction (Part 1 of 3)
WP2772	S Phase
WP2755	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
WP2720	Signaling by NOTCH1
WP2637	Structural Pathway of Interleukin 1 (IL-1)
WP2586	Aryl Hydrocarbon Receptor
WP2571	Polycystic Kidney Disease Pathway
WP254	Apoptosis
WP2446	Retinoblastoma (RB) in Cancer
WP2431	Spinal Cord Injury
WP2377	Integrated Pancreatic Cancer Pathway
WP2363	Gastric cancer network 2
WP23	B Cell Receptor Signaling Pathway
WP2263	Prostate Cancer
WP2249	Metastatic brain tumor
WP2203	TSLP Signaling Pathway
WP2064	Neural Crest Differentiation
WP205	IL-7 Signaling Pathway
WP2032	TSH signaling pathway
WP1984	Integrated Breast Cancer Pathway
WP1971	Integrated Cancer pathway
WP1858	Mitotic G1-G1/S phases
WP1742	TP53 Network
WP1545	miRNAs involved in DNA damage response
WP1530	miRNA Regulation of DNA Damage Response
WP127	IL-5 Signaling Pathway

目标的蛋白质ID

标题	内容
TARGETID	T85651
UNIPROID	MYC_HUMAN
TARGNAME	Myc messenger RNA (MYC mRNA)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Myc messenger RNA (MYC mRNA)	MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA

标题

内容

Myc messenger RNA (MYC mRNA)

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