靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T85529

FORMERID

TTDC00208

UNIPROID

CD28_HUMAN

TARGNAME

T-cell-specific surface glycoprotein CD28 (CD28)

GENENAME

CD28

TARGTYPE

Successful target

SYNONYMS

TP44; CD28-S2

FUNCTION

Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

PDBSTRUC

5GJI; 5GJH; 5AUL; 3WA4; 1YJD

SEQUENCE

MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS

DRUGINFO

Belatacept

DRUGINFO

AB-103

DRUGINFO

Lulizumab pegol

DRUGINFO

AU101

DRUGINFO

REGN5678

DRUGINFO

CD19-CAR and CD28-CAR T Cells

Phase 1

DRUGINFO

D0JY0M

CD28 and CD137 CAR-T Cells

DRUGINFO

SAR442257

DRUGINFO

TGN-1412

Discontinued in Phase 1

DRUGINFO

D0V9LF

Anti-CD28

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04514	Cell adhesion molecules (CAMs)
hsa04660	T cell receptor signaling pathway
hsa04672	Intestinal immune network for IgA production
hsa04940	Type I diabetes mellitus
hsa05162	Measles
hsa05320	Autoimmune thyroid disease
hsa05322	Systemic lupus erythematosus
hsa05323	Rheumatoid arthritis
hsa05330	Allograft rejection
hsa05332	Graft-versus-host disease
hsa05416	Viral myocarditis

目标的 Wiki 路径数据

标题	内容
WP69	TCR Signaling Pathway
WP453	Inflammatory Response Pathway
WP2684	Host Interactions of HIV factors
WP2653	PIP3 activates AKT signaling
WP2583	T-Cell Receptor and Co-stimulatory Signaling
WP2328	Allograft Rejection
WP1799	Costimulation by the CD28 family

目标的蛋白质ID

标题	内容
TARGETID	T85529
UNIPROID	CD28_HUMAN
TARGNAME	T-cell-specific surface glycoprotein CD28 (CD28)
TARGTYPE	Successful target

目标的序列数据

标题	内容
T-cell-specific surface glycoprotein CD28 (CD28)	MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS

最新招商产品更多>>