当前位置：药药网 / 数据中心 /靶点信息(本栏目收费,不能显示细节,电话13136136841)
靶点信息28(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Lymphotoxin-alpha (LTA)
TARGTYPE
Clinical trial target
SYNONYMS
Tumor necrosis factor ligand superfamily member 1; TNFSF1; TNFB; TNF-beta; LT-alpha
FUNCTION
In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM.
PDBSTRUC
4MXW; 4MXV; 1TNR
BIOCLASS
Cytokine: tumor necrosis factor
SEQUENCE
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04064:NF-kappa B signaling pathway
KEGGPATH
hsa04668:TNF signaling pathway
KEGGPATH
hsa04940:Type I diabetes mellitus
KEGGPATH
hsa05166:HTLV-I infection
KEGGPATH
hsa05168:Herpes simplex infection
REACPATH
R-HSA-5668541:TNFR2 non-canonical NF-kB pathway
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04064 |
|
| hsa04668 |
|
| hsa04940 |
|
| hsa05166 |
|
| hsa05168 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Lymphotoxin-alpha (LTA) |
|