TARGETID

T84634

FORMERID

TTDC00232

UNIPROID

CP26A_HUMAN

TARGNAME

Cytochrome P450 26 (CYP26A1)

GENENAME

CYP26A1

TARGTYPE

Clinical trial target

SYNONYMS

Retinoic acid-metabolizing cytochrome; Retinoic acid inducible enzyme; Retinoic acid 4-hydroxylase; P450RAI; P450 retinoic acid-inactivating 1; HP450RAI; Cytochrome P450RAI; CYP26A1

FUNCTION

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.

BIOCLASS

Paired donor oxygen oxidoreductase

ECNUMBER

EC 1.14.13.-

SEQUENCE

MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI

DRUGINFO

LIAROZOLE

DRUGINFO

Rambazole

DRUGINFO

4-((+/-)-(1H-imidazol-1-yl)-(E)-methylretinoate

DRUGINFO

4-((+/-)-(1H-imidazol-1-yl)-(E)-retinoic acid

KEGGPATH

hsa00830:Retinol metabolism

KEGGPATH

hsa01100:Metabolic pathways

WIKIPATH

WP1879:Phase 1 - Functionalization of compounds

WIKIPATH

WP236:Adipogenesis

WIKIPATH

WP299:Nuclear Receptors in Lipid Metabolism and Toxicity