靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T80387

FORMERID

TTDS00410

UNIPROID

GBRB2_HUMAN

TARGNAME

GABA(A) receptor beta-2 (GABRB2)

GENENAME

GABRB2

TARGTYPE

Successful target

SYNONYMS

GABRB2; GABA(A) receptor subunit beta-2

FUNCTION

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.

PDBSTRUC

6D6U; 6D6T

BIOCLASS

Neurotransmitter receptor

SEQUENCE

MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN

DRUGINFO

Allopregnanolone

DRUGINFO

Ethchlorvynol

DRUGINFO

THIOCOLCHICOSIDE

DRUGINFO

ZK-93423

DRUGINFO

GSK683699

DRUGINFO

ELTANOLONE

Discontinued in Phase 3

DRUGINFO

D05EVI

U-78875

Discontinued in Phase 1

DRUGINFO

D0V4GI

CGS-9896

Terminated

DRUGINFO

D09ACO

(2E,4S)-4-ammoniopent-2-enoate

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction
hsa04723	Retrograde endocannabinoid signaling
hsa04726	Serotonergic synapse
hsa04727	GABAergic synapse
hsa05032	Morphine addiction
hsa05033	Nicotine addiction

目标的 Wiki 路径数据

标题	内容
WP2754	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP2670	Iron uptake and transport

目标的蛋白质ID

标题	内容
TARGETID	T80387
UNIPROID	GBRB2_HUMAN
TARGNAME	GABA(A) receptor beta-2 (GABRB2)
TARGTYPE	Successful target

目标的序列数据

标题	内容
GABA(A) receptor beta-2 (GABRB2)	MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN

标题

内容

GABA(A) receptor beta-2 (GABRB2)

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