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靶点信息17(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
eIF4E-BP2 messenger RNA (eIF4E-BP2 mRNA)
TARGTYPE
Clinical trial target
SYNONYMS
eIF4E-binding protein 2 (mRNA); Eukaryotic translation initiation factor 4E-binding protein 2 (mRNA); 4E-BP2 (mRNA)
FUNCTION
Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Repressor of translation initiation involved in synaptic plasticity, learning and memory formation.
SEQUENCE
MSSSAGSGHQPSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIEDSKVEVNNLNNLNNHDRKHAVGDDAQFEMDI
KEGGPATH
hsa03013:RNA transport
WIKIPATH
WP107:Translation Factors
目标的蛋白质ID
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目标的序列数据
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| eIF4E-BP2 messenger RNA (eIF4E-BP2 mRNA) |
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