TARGETID

T79591

FORMERID

TTDS00381

UNIPROID

THA_HUMAN

TARGNAME

Thyroid hormone receptor alpha (THRA)

GENENAME

THRA

TARGTYPE

Successful target

SYNONYMS

V-erbA-related protein 7; THRA2; THRA1; Nuclear receptor subfamily 1 group A member 1; NR1A1; ERBA1; EAR7; EAR-7; C-erbA-alpha; C-erbA-1

FUNCTION

High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription.

PDBSTRUC

4LNX; 4LNW; 3JZB; 3ILZ; 3HZF

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP

DRUGINFO

Dextrothyroxine Sodium

DRUGINFO

Levothyroxine

DRUGINFO

Liothyronine

DRUGINFO

BCT303

DRUGINFO

tiratricol

DRUGINFO

(3,5-Dibromo-4-hexyloxy-phenyl)-acetic acid

DRUGINFO

(E)-1-(4-heptylphenyl)but-2-en-1-one

DRUGINFO

(Z)-4-(4-hexylphenylamino)-4-oxobut-2-enoic acid

DRUGINFO

1-(4-hexylphenyl)-3-morpholinopropan-1-one