靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T79473

FORMERID

TTDS00254

UNIPROID

LSHR_HUMAN

TARGNAME

Luteinizing hormone receptor (LHCGR)

GENENAME

LHCGR

TARGTYPE

Successful target

SYNONYMS

Luteinizing hormone-releasing hormone receptor; LSH-R; LHRH receptor; LHCGR; LH/CG-R

FUNCTION

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

PDBSTRUC

1XUL; 1LUT

BIOCLASS

GPCR rhodopsin

SEQUENCE

MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC

DRUGINFO

D0W6SS

Choriogonadotropin alfa

Approved

DRUGINFO

D0J0LI

Chorionic Gonadotropin

DRUGINFO

Lutropin alfa

DRUGINFO

ML-04

DRUGINFO

Org-43902

DRUGINFO

LDI-200

Discontinued in Phase 3

DRUGINFO

D00TTS

Human chorionic gonadotropin

Terminated

DRUGINFO

D04CTP

EP-200

Investigative

KEGGPATH

hsa04020:Calcium signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04913	Ovarian steroidogenesis
hsa04917	Prolactin signaling pathway

目标的 Wiki 路径数据

标题	内容
WP455	GPCRs, Class A Rhodopsin-like
WP34	Ovarian Infertility Genes
WP24	Peptide GPCRs
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T79473
UNIPROID	LSHR_HUMAN
TARGNAME	Luteinizing hormone receptor (LHCGR)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Luteinizing hormone receptor (LHCGR)	MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC

标题

内容

Luteinizing hormone receptor (LHCGR)

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