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靶点信息28(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Tryptophan 5-hydroxylase 1 (TPH1)
TARGTYPE
Clinical trial target
SYNONYMS
Tryptophan 5-monooxygenase 1; TRPH; TPRH
FUNCTION
Responsible for addition of the -HO group (hydroxylation) to the 5 position to form the amino acid 5-hydroxytryptophan (5-HTP), which is the initial and rate-limiting step in the synthesis of the neurotransmitter serotonin.
PDBSTRUC
5TPG; 5L01; 5J6D; 3HFB; 3HF8
BIOCLASS
Paired donor oxygen oxidoreductase
SEQUENCE
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
DRUGINFO
6-fluorotryptophan
DRUGINFO
alpha-propyldopacetamide
KEGGPATH
hsa00380:Tryptophan metabolism
KEGGPATH
hsa01100:Metabolic pathways
KEGGPATH
hsa04726:Serotonergic synapse
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00380 |
|
| hsa01100 |
|
| hsa04726 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP2693 |
|
| WP706 |
|
| WP550 |
|
| WP465 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Tryptophan 5-hydroxylase 1 (TPH1) |
|