TARGETID

T78692

FORMERID

TTDS00150

UNIPROID

KCNJ5_HUMAN

TARGNAME

Inward rectifier potassium channel Kir3.4 (KCNJ5)

GENENAME

KCNJ5

TARGTYPE

Clinical trial target

SYNONYMS

Potassium channel, inwardly rectifying, subfamily J, member 5; KCNJ5; KATP-1; KATP channel; Inward rectifier K+ channel Kir3.4; Heart KATP channel; GIRK4; Cardiac inward rectifier; CIR

FUNCTION

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

BIOCLASS

Inward rectifier potassium channel

SEQUENCE

MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV

DRUGINFO

phorbol 12-myristate 13-acetate

DRUGINFO

PIP2

KEGGPATH

hsa04713:Circadian entrainment

KEGGPATH

hsa04723:Retrograde endocannabinoid signaling

KEGGPATH

hsa04726:Serotonergic synapse

KEGGPATH

hsa04728:Dopaminergic synapse

KEGGPATH

hsa04915:Estrogen signaling pathway

KEGGPATH

hsa04921:Oxytocin signaling pathway

KEGGPATH

hsa05032:Morphine addiction

WIKIPATH

WP2669:Potassium Channels