TARGETID

T78656

FORMERID

TTDR01194

UNIPROID

5HT1F_HUMAN

TARGNAME

5-HT 1F receptor (HTR1F)

GENENAME

HTR1F

TARGTYPE

Successful target

SYNONYMS

Serotonin receptor 1F; HTR1EL; 5-hydroxytryptamine receptor 1F; 5-HT1F receptor; 5-HT1F; 5-HT-1F

FUNCTION

Functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. G-protein coupled receptor for 5-hydroxytryptamine (serotonin).

BIOCLASS

GPCR rhodopsin

SEQUENCE

MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC

DRUGINFO

Lasmiditan

DRUGINFO

Metergolin

DRUGINFO

LY-334370

DRUGINFO

[125I]LSD

DRUGINFO

1-naphthylpiperazine

DRUGINFO

2-methyl-5-HT

DRUGINFO

5-BODMT

DRUGINFO

5-CT

DRUGINFO

alpha-methyl-5-HT

DRUGINFO

BRL-15572